E-resources
-
Sunami, Kuniko; Ichikawa, Hitoshi; Kubo, Takashi; Kato, Mamoru; Fujiwara, Yutaka; Shimomura, Akihiko; Koyama, Takafumi; Kakishima, Hiroki; Kitami, Mayuko; Matsushita, Hiromichi; Furukawa, Eisaku; Narushima, Daichi; Nagai, Momoko; Taniguchi, Hirokazu; Motoi, Noriko; Sekine, Shigeki; Maeshima, Akiko; Mori, Taisuke; Watanabe, Reiko; Yoshida, Masayuki; Yoshida, Akihiko; Yoshida, Hiroshi; Satomi, Kaishi; Sukeda, Aoi; Hashimoto, Taiki; Shimizu, Toshio; Iwasa, Satoru; Yonemori, Kan; Kato, Ken; Morizane, Chigusa; Ogawa, Chitose; Tanabe, Noriko; Sugano, Kokichi; Hiraoka, Nobuyoshi; Tamura, Kenji; Yoshida, Teruhiko; Fujiwara, Yasuhiro; Ochiai, Atsushi; Yamamoto, Noboru; Kohno, Takashi
Cancer science, April 2019, 2019-Apr, 2019-04-00, 20190401, Volume: 110, Issue: 4Journal Article
Next‐generation sequencing (NGS) of tumor tissue (ie, clinical sequencing) can guide clinical management by providing information about actionable gene aberrations that have diagnostic and therapeutic significance. Here, we undertook a hospital‐based prospective study (TOP‐GEAR project, 2nd stage) to investigate the feasibility and utility of NGS‐based analysis of 114 cancer‐associated genes (the NCC Oncopanel test). We examined 230 cases (comprising more than 30 tumor types) of advanced solid tumors, all of which were matched with nontumor samples. Gene profiling data were obtained for 187 cases (81.3%), 111 (59.4%) of which harbored actionable gene aberrations according to the Clinical Practice Guidelines for Next Generation Sequencing in Cancer Diagnosis and Treatment (Edition 1.0) issued by 3 major Japanese cancer‐related societies. Twenty‐five (13.3%) cases have since received molecular‐targeted therapy according to their gene aberrations. These results indicate the utility of tumor‐profiling multiplex gene panel testing in a clinical setting in Japan. This study is registered with UMIN Clinical Trials Registry (UMIN 000011141). The results of the TOP‐GEAR project (UMIN 000011141) indicate the utility of tumor‐profiling multiplex gene panel testing in a clinical setting in Japan.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.