E-resources
Peer reviewed
-
Thévenot, Thierry; Bureau, Christophe; Oberti, Frédéric; Anty, Rodolphe; Louvet, Alexandre; Plessier, Aurélie; Rudler, Marika; Heurgué-Berlot, Alexandra; Rosa, Isabelle; Talbodec, Nathalie; Dao, Thong; Ozenne, Violaine; Carbonell, Nicolas; Causse, Xavier; Goria, Odile; Minello, Anne; De Ledinghen, Victor; Amathieu, Roland; Barraud, Hélène; Nguyen-Khac, Eric; Becker, Claire; Paupard, Thierry; Botta-Fridlung, Danielle; Abdelli, Naceur; Guillemot, François; Monnet, Elisabeth; Di Martino, Vincent
Journal of hepatology, 04/2015, Volume: 62, Issue: 4Journal Article
Background & Aims Albumin infusion improves renal function and survival in cirrhotic patients with spontaneous bacterial peritonitis (SBP) but its efficacy in other types of infections remains unknown. We investigated this issue through a multicenter randomized controlled trial. Methods A total of 193 cirrhotic patients with a Child-Pugh score greater than 8 and sepsis unrelated to SBP were randomly assigned to receive antibiotics plus albumin (1.5 g/kg on day 1 and 1 g/kg on day 3; albumin group ALB: n = 96) or antibiotics alone (control group CG: n = 97). The primary endpoint was the 3-month renal failure rate (increase in creatinine ⩾50% to reach a final value ⩾133 μmol/L). The secondary endpoint was 3-month survival rate. Results Forty-seven (24.6%) patients died (ALB: n = 27 vs. CG: n = 20; 3-month survival: 70.2% vs. 78.3%; p = 0.16). Albumin infusion delayed the occurrence of renal failure (mean time to onset, ALB: 29.0 ± 21.8 vs. 11.7 ± 9.1 days, p = 0.018) but the 3-month renal failure rate was similar (ALB: 14.3% vs. CG: 13.5%; p = 0.88). By multivariate analysis, MELD score ( p <0.0001), pneumonia ( p = 0.0041), hyponatremia ( p = 0.031) and occurrence of renal failure ( p <0.0001) were predictors of death. Of note, pulmonary edema developed in 8/96 (8.3%) patients in the albumin group of whom two died, one on the day and the other on day 33 following albumin infusion. Conclusions In cirrhotic patients with infections other than SBP, albumin infusion delayed onset of renal failure but did not improve renal function or survival at 3 months. Infusion of large amounts of albumin should be cautiously administered in the sickest cirrhotic patients.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.