Strokes are among the leading conditions that lead to disability and death. Currently, there is a lack of ideal nursing care for stroke patients. The aim of this study is to assess the effect of combining evidence-based nursing and clinical nursing pathway to establish a nursing model to provide care for patients who suffered a stroke. A comprehensive search of online-based databases will be carried out to identify relevant publications, the databases include EMBASE, Cochrane Library, PubMed, VIP databases, Chinese National Knowledge Infrastructure, and WanFang database. The search will consider all Randomized Controlled Trials, interrupted time series studies, and controlled before and after studies, all related to providing care for neurology and strokes by combining evidence-based nursing and clinical nursing pathway to elevate access and outcomes for patients with stroke. The language of publications will be restricted to English and Chinese. The author will select studies, extract data, and evaluate the quality of the involved articles. RevMan 5.3 software will be employed to perform all statistical analysis. The outcomes of the proposed study will provide scientific evidence for the nursing care of evidence-based nursing combined with clinical nursing pathway for stroke patients. The planned systematic analysis will be first to examine the effect of combining evidence-based nursing and clinical nursing pathway to present a nursing model to treat stroke patients. November 16, 2021.osf.io/6zr5a/. (https://osf.io/6zr5a/).