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Yu, Geng-Nan; Huang, Jun-Chao; Li, Li; Liu, Ruo-Tong; Cao, Jie-Qiong; Wu, Qiong; Zhang, Shuang-Yan; Wang, Cheng-Xi; Mei, Wen-Jie; Zheng, Wen-Jie
RSC advances, 01/2018, Volume: 8, Issue: 53Journal Article
The development of Ru(ii) complexes as luminescent probes has attracted increasing attention in recent decades. In this study, the nanosized polymers of two Ru(ii) complexes Ru(phen) (dppz)(ClO ) (1, phen = 1,10-phenanthrolin; dppz = dipyrido3,2- :2',3'- phenazine) and Ru(phen) (Br-dppz)(ClO ) (2, Br-dppz = 11-bromodipyrido3,2- :2',3'- phenazine) with oligonucleotides were prepared and investigated as potential tumor-imaging probes. The formation of the nanosized polymers, which had an average width of 125-438 nm and an average height of 3-6 nm, for 1 and 2@oligonucleotides were observed through atomic force microscopy. The emission spectra indicated that the luminescence of 1 and 2 markedly increased after binding to oligonucleotides and double-strand DNA (calf thymus DNA), respectively. Moreover, further studies indicated that 1@oligonucleotides and 2@oligonucleotides can easily enter into tumor cells and selectively highlight the tumor area in the zebrafish bear xenograft tumor (MDA-MB-231). In summary, this study demonstrated that 1@oligonucleotides and 2@oligonucleotides could be developed as potential tumor-imaging luminescent probes for clinical diagnosis and therapy.
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