E-resources
-
Madel, Maria-Bernadette; Ibáñez, Lidia; Ciucci, Thomas; Halper, Julia; Rouleau, Matthieu; Boutin, Antoine; Hue, Christophe; Duroux-Richard, Isabelle; Apparailly, Florence; Garchon, Henri-Jean; Wakkach, Abdelilah; Blin-Wakkach, Claudine
eLife, 05/2020, Volume: 9Journal Article
Bone destruction relies on interactions between bone and immune cells. Bone-resorbing osteoclasts (OCLs) were recently identified as innate immune cells activating T cells toward tolerance or inflammation. Thus, pathological bone destruction not only relies on increased osteoclast differentiation, but also on the presence of inflammatory OCLs (i-OCLs), part of which express . Here, we investigated the contribution of mouse Cx3cr1 and Cx3cr1 i-OCLs to bone loss. We showed that Cx3cr1 and Cx3cr1 i-OCLs differ considerably in transcriptional and functional aspects. Cx3cr1 i-OCLs have a high ability to resorb bone and activate inflammatory CD4 T cells. Although Cx3cr1 i-OCLs are associated with inflammation, they resorb less and have in vitro an immune-suppressive effect on Cx3cr1 i-OCLs, mediated by PD-L1. Our results provide new insights into i-OCL heterogeneity. They also reveal that different i-OCL subsets may interact to regulate inflammation. This contributes to a better understanding and prevention of inflammatory bone destruction.
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.