PurposeThe desire for firms to gain competitive advantage and improve performance has resulted in the adoption of several practices. Green supply chain practices (GSCPs), just in time (JIT) and total quality management (TQM) are some of the practices adopted by firms to improve operational performance (OP) and business performance (BP). This study examines the direct influence of GSCPs, JIT and TQM on operational performance and BP. The study further analyzes the synergy of GSCPs, JIT and TQM on OP and BP.Design/methodology/approachThis study employs the quantitative approach of research by using questionnaire to gather data from manufacturing managers and supply chain managers of 140 manufacturing firms in Ghana. The research uses partial least square structural equation modeling (PLS–SEM) to analyze the survey data.FindingsThe results of the analysis show that GSCPs, TQM and JIT positively influence both OP and BP. The findings reveal that GSCPs combine with JIT and TQM to improve OP and BP significantly. However, the synergy between green supply chain and TQM creates more value for both OP and BP than the synergy between GSCPs and JIT.Originality/valueThe study proposes a research model that examines both the individual and combined influence of GSCPs, TQM and JIT on both OP and BP from the developing country perspective. The study models GSCPs as an antecedent of JIT and TQM, which has not been explored.