α‐Glucosidase Inhibitory Cycloartanes from the Vietnamese Combretum quadrangulare

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α‐Glucosidase Inhibitory Cycloartanes from the Vietnamese Combretum quadrangulare

Nguyen, Huu‐Hung; Duong, Thuc‐Huy; Truong Nguyen, Huy; Vo, Thanh‐Sang; Mai, Dinh‐Tri; Nguyen Thi Thuong, Huyen; Bui, Xuan‐Hao; Nguyen, Ngoc‐Hong; Do, Thi‐Hong‐Tuoi

Chemistry & biodiversity, October 2022, 2022-10-00, 20221001, Volume: 19, Issue: 10

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Leaves of Combretum quadrangulare Kurz showed potent α‐glucosidase inhibition. Two new cycloartane‐type triterpenes, combretic acids D and E were isolated from the bioactive fraction. The chemical structures were determined using NMR and MS methods. Combretic acid D represents for the first cycloartane having a dihydrofuran ring in the side chain. Combretic acids D and E showed significant α‐glucosidase inhibition, with IC50 values of 13.9 and 30.7 μM, respectively. Combretic acid D was determined to be a non‐competitive type in the kinetic study. The docking study in combination with dynamic simulations of this compound provided the molecular understanding of α‐glucosidase inhibition.

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