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Vuksan, Vladimir; Sievenpiper, John L; Jovanovski, Elena; Jenkins, Alexandra L; Komishon, Allison; Au-Yeung, Fei; Zurbau, Andreea; Ho, Hoang V.T; Li, Dandan; Smircic-Duvnjak, Lea
Applied physiology, nutrition, and metabolism, 07/2020, Volume: 45, Issue: 7Journal Article
We applied the Framingham risk equation in healthy, metabolic syndrome, and diabetes populations, following treatment with viscous fibre from konjac-based blend (KBB). KBB yielded reduction in estimated risk score by 16% (1.04 ± 0.03 vs. 0.87 ± 0.04, p < 0.01) in type 2 diabetes, 24% (1.08 ± 0.01 vs. 0.82 ± 0.02, p < 0.01) in metabolic syndrome, and 25% (1.09 ± 0.05 vs. 0.82 ± 0.06, p < 0.01) in healthy individuals. Drivers for decreased risk were improvements in blood cholesterol and systolic blood pressure. The composite coronary heart disease risk across populations was reduced 22% (p < 0.01). Novelty Viscous fibre from konjac-xanthan reduced 10-year relative coronary heart disease using Framingham Risk Score across the glycemic status spectrum.
