In this paper, a new perspective of food packaging design is proposed by using the Life Cycle Assessment (LCA) approach, in which shelf life and food loss probability were taken into account. The study focused on twenty-four scenarios of packaging of a ripened cheese obtained from sheep milk, in order to analyze the environmental implications of different packaging systems in terms of potential food loss. The aim is to provide an eco-indicator able to quantify the environmental indirect effects related to the different choices in the food packaging. Results highlighted that, by considering only the direct inputs and outputs of the packaging system, thinner and recyclable packaging materials sealed in air are more sustainable from an environmental point of view. On the contrary, if indirect effects of food loss probability are also taken into account (e.g. production and transport of cheese in order to reconstruct the stockpile), multilayer systems under modified headspace conditions are preferred packaging solutions. This is consequence of the fact that cheese production brings about high environmental impacts if compared to the other phases of the life cycle, therefore, the environmental implications of the choices adopted for the packaging phase are more affected from the capacity of reducing food losses than from the production and disposing of packaging materials. •A new perspective of food packaging design is proposed.•The approach utilized was based on Life Cycle Assessment (LCA).•The novelty consists of taking into account both product shelf life and food loss probability.•The best packaging are able to guarantee high shelf life and low food loss probability.