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Shirai, Ryuichi; Morita, Koji; Nishikawa, Asuka; Nakatsu, Noriyuki; Fukui, Yasuhisa; Morisaki, Naoko; Hashimoto, Yuichi
Tetrahedron letters, 12/1998, Volume: 39, Issue: 51Journal Article
Phosphatidylinositol 3,4,5-trisphosphate analogs with saturated diacylglycerol substructure have been designed, focusing on their feactivity with PIP3 5-phosphatase. Dephosphorylation of native PIP3 was competitively inhibited in the presence of synthetic PIP3 C2 and PIP3 C4, respectively. Phosphatidylinositol 3,4,5-trisphosphate analogs with saturated diacylglycerol substructure have been designed, focusing on their reactivity with PIP3 5-phosphatase. Dephosphorylation of native PIP3 was competitively inhibited in the presence of synthetic PIP3 c2 and PIP3 c4, respectively.
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