Fasciolosis is an important plant borne trematode zoonosis in ruminants caused by the Fasciola hepatica and Fasciola gigentica, It is classified as a neglected tropical disease and found in more than 50 countries especially where sheep and cattle are reared. Fasciolosis is a serious animal health problems in many rural and urban areas of world, causing significant financial losses due to decrease in production and viscera condemnation in animals. Accurate diagnosis of fasciolosis is always remained a challenging task for the field practitioners. There is no comprehensive summary on the occurrence and distribution of the infection at international level. Therefore, we intended to provide a complete overview on the prevalence and epidemiology of fasciolosis in farm animals from a global prospective. It includes to map the global distribution of fasciolosis in different areas of the world to identify the endemic regions which may be a source of potential disease outbreak. The financial liability related to fasciolosis on the livestock production has also been addressed. For this purpose, the published data during 2000–2015 (15 years) on fasciolosis was reviewed and collected by electronic literature search of four databases including Google, PubMed, Science Direct, and Web of Science. Data presented are contemplated to enhance our current understanding of the parasite's geographical distribution, host range, and economic losses. Information provided would be useful for the application of more effective control strategies against fasciolosis in different geo-economics regions of the world. •Fasciolosis is an important plant borne trematode zoonosis in ruminants caused by Fasciola hepatica and Fasciola gigentica.•Published data (2000–2015) on fasciolosis was reviewed to check epidemiology, global prevalence & economic losses in ruminants.•It is a widespread disease in ruminants round the world and causes huge financial losses to butchers, farmers and consumers.•Countries with higher prevalence are a potential source of disease transmission & are threat for possible future outbreaks.•The countries with higher prevalence require to follow proper control of intermediate host & strategic therapeutic treatment.