In this paper, the sliding structure morphology, mechanical and tribological behavior of thermoplastic polyurethanes (TPU) under different conditions were studied. The coefficient of friction of TPU stabilizes rapidly at relatively low values and the wear rate increased. High load conditions significantly improved TPU's coefficient of friction and wear rate. However, a high sliding speed was helpful to form a transfer flimsy. Therefore, the coefficient of friction and wear rate of TPU were reduced at higher sliding speeds. The morphology of the wear surface of TPU indicated that the main wear process was viscous wear and wears fatigue under dry and sliding conditions. Using open-source 3D printer is common to use a series of fillers mode and density to reduce time and consumption. Involving the same FDM technique, it is an important to evaluate its strength with this technology. Herein, the effects of more adjustable variables, such as frequencies, infill patterns, density and loads, has been evaluated in detail.