...the region as a whole is facing a humanitarian crisis borne out of political instability, corruption, social unrest, fragile health systems, and perhaps most importantly, longstanding and pervasive inequality—in income, health care, and education—which has been woven into the social and economic fabric of the region. The overall population health status in Latin America and the Caribbean has improved, as measured by life expectancy, under-5 mortality, and maternal mortality, but progress remains unequal across and within countries. The syndemic nature of the pandemic—a combination of viral infection and non-communicable diseases embedded in social inequities—is acute in the region.