•ANITA-NC is a code system, developed in ENEA-Bologna, able to treat the activation induced by neutral and charged particles.•ANITA-NC uses EAF-2010 activation cross section libraries for neutrons, deuterons and protons.•A new neutron activation cross section library in EAF format was produced based on TENDL-2017 evaluated data.•Some application examples of neutron, deuteron and proton activation are shown.•A good agreement between ANITA-NC and FISPACT-II results is found. ANITA-NC (Analysis of Neutron Induced Transmutation and Activation – Neutral and Charged) is an inventory system (code and libraries) developed in ENEA-Bologna, capable of modelling material activation induced by neutral or charged projectiles (i.e. neutrons, protons, deuterons, alphas or gammas). It is an extension of the previous ANITA versions. ANITA-NC requires group-wise activation cross-section libraries in EAF format. It actually uses the most recent libraries in this format, that is the EAF-2010 libraries in the VITAMIN-J+ (211) energy group structure, up to 55 MeV. For neutrons, a new library in a 271 energy group structure up to 200 MeV, based on TENDL-2017, was produced. The decay data used in ANITA-NC are based on the JEFF-3.1.1 Radioactive Decay Data Library. This paper summarizes the main characteristics of the ANITA-NC activation system. Some application cases and an example of data and code validation on experimental results are shown.