Objective: This study aimed to investigate the actual situation of perinatal depression and related factors considering the social impact of COVID-19.Method: This was a cross-sectional study using an online self-administered questionnaire in October 2020, and responses were obtained from 739 pregnant women and 1,603 mothers less than a year postpartum.Results: Regarding the experience of crises related to the Coronavirus disease 2019 (COVID-19) pandemic, “experiencing criticism for taking the child to public places” was found to be 18.1%, “reduced income” was 38.0%, and “fear of COVID-19 illness” was 77.2%. The logistic regression analysis showed that factors associated with the high risk of perinatal depression were ‘history of mental disorders’, ‘academic background’, ‘maternal and infant health condition’ and ‘social impact of COVID-19, varied depending on timing and delivery history.Conclusion: Depression among pregnant women and mothers increased in the COVID-19 pandemic, and it suggested the need for care considering the social impact of COVID-19.