The Co(II)Cl2·6H2O catalyzed C–H activation/direct arylation of imidazo1,2‐apyridine with aryl/heteroaryl iodide is reported. The cost effective, ligand and additive free protocol using KOAc successfully afforded 3‐arylimidazo1,2‐apyridines in good yields. Imidazo1,2‐apyridines with electron withdrawing and electron donating substituents with various aryl iodides are well tolerated. The reaction is performed in a Screw‐top V‐Vial® to expedite the synthesis. The antibacterial 3‐naphthyl imidazo1,2‐apyridine is smoothly prepared using this protocol. A practical protocol for the C‐3 arylation of imidazo1,2‐apyridines with aryl/heteroaryl iodides using Co(II)Cl2·6H2O is reported. The reaction can be performed in a Screw‐top V‐Vial® to expedite the synthesis.