COX-2-derived endocannabinoid metabolites as novel inflammatory mediators

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COX-2-derived endocannabinoid metabolites as novel inflammatory mediators

Alhouayek, Mireille; Muccioli, Giulio G

Trends in pharmacological sciences (Regular ed.), 06/2014, Volume: 35, Issue: 6

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Highlights • PG-G and PG-EA are COX-2-derived metabolites of endocannabinoids. • COX-2 is at the center of crosstalk between the endocannabinoid and prostanoid systems. • PG-G and PG-EA represent novel lipid mediators in inflammation. • COX-2 substrate-selective inhibitors control PG-G and PG-EA levels and activity. • Antagonists of their receptors are being characterized.

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Alhouayek, Mireille | Muccioli, Giulio G

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