UP - logo
E-resources
Peer reviewed Open access
  • Drug interactions and the e...
    Kishony, Roy; Yeh, Pamela J; Hegreness, Matthew J; Aiden, Aviva Presser

    Nature reviews. Microbiology, 06/2009, Volume: 7, Issue: 6
    Journal Article

    Large-scale, systems biology approaches now allow us to systematically map synergistic and antagonistic interactions between drugs. Consequently, drug antagonism is emerging as a powerful tool to study biological function and relatedness between cellular components as well as to uncover mechanisms of drug action. Furthermore, theoretical models and new experiments suggest that antagonistic interactions between antibiotics can counteract the evolution of drug resistance.