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Gail, Mitchell H
Lancet oncology/Lancet. Oncology, June 2019, 2019-06-00, 20190601, Volume: 20, Issue: 6Journal Article
...Prof-SC is a high-risk cohort. ...BCRAT recommends the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) model for such women. To evaluate BCRAT, one should restrict attention to those without BRCA1 or BRCA2 mutations, in whom BCRAT performed surprisingly well.1 The expected-to-observed ratio was 0·97 (95% CI 0·89–1·06), indicating excellent overall calibration. ...the concordance statistic for BRCAT (0·64) differed little from the values attained by the BOADICEA (0·65) and International Breast Cancer Intervention Study (0·66) models, which require more extensive information.
