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Pérez-Lago, Laura; Martínez-Lozano, Helena; Pajares Díaz, Jose Antonio; Díaz Gómez, Arantxa; Machado, Marina; Sola-Campoy, Pedro J; Herranz, Marta; Buenestado-Serrano, Sergio; Valerio, Maricela; Olmedo, María; Andrés Zayas, Cristina; Comas, Iñaki; González Candelas, Fernando; Bañares, Rafael; Catalán, Pilar; Muñoz, Patricia; García de Viedma, Darío
The Journal of infectious diseases, 09/2021, Volume: 224, Issue: 5Journal Article
Abstract A 77-year-old man (case R) with previous diagnosis of a mild COVID-19 episode was hospitalized 35 days later. On day 23 postadmission, he developed a second COVID-19 episode, now severe, and finally died. Initially, case R’s COVID-19 recurrence was interpreted as a reinfection due to the exposure to a SARS-CoV-2 RT-PCR–positive roommate. However, whole-genome sequencing indicated that case R’s recurrence corresponded to a reactivation of the strain involved in his first episode. Case R’s reactivation had major consequences, leading to a more severe episode, and causing subsequent transmission to another 2 hospitalized patients, 1 of them with fatal outcome.
