E-resources
-
Zheng, Zhuqing; Wang, Xihong; Li, Ming; Li, Yunjia; Yang, Zhirui; Wang, Xiaolong; Pan, Xiangyu; Gong, Mian; Zhang, Yu; Guo, Yingwei; Wang, Yu; Liu, Jing; Cai, Yudong; Chen, Qiuming; Okpeku, Moses; Colli, Licia; Cai, Dawei; Wang, Kun; Huang, Shisheng; Sonstegard, Tad S; Esmailizadeh, Ali; Zhang, Wenguang; Zhang, Tingting; Xu, Yangbin; Xu, Naiyi; Yang, Yi; Han, Jianlin; Chen, Lei; Lesur, Joséphine; Daly, Kevin G; Bradley, Daniel G; Heller, Rasmus; Zhang, Guojie; Wang, Wen; Chen, Yulin; Jiang, Yu
Science advances, 05/2020, Volume: 6, Issue: 21Journal Article
Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. One introgressed locus with a strong signature of selection harbors the gene, which encodes a gastrointestinally secreted mucin. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. Another locus with a strong signal of selection may be related to behavior. The selected alleles at these two loci emerged in domestic goats at least 7200 and 8100 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Tracking these archaeologically cryptic evolutionary transformations provides new insights into the mechanisms of animal domestication.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.