Gastrointestinal angiodysplasia (GIA) is the most common digestive tract vascular malformation, often causing recurrent gastrointestinal bleeding. Despite association with certain hereditary diseases 1,2,3, most GIAs are acquired, associated with aortic stenosis, hemodialysis, malignancies, or liver cirrhosis or idiopathic, and they appear among the elderly (>60 years) 4. Advances in endoscopy brought about management improvements, but due to numerous lesions disseminated over the digestive tract, treatment of GIA remains a clinical challenge. Novel studies suggested that the use of thalidomide might be beneficial in these patients due to its antiangiogenic properties 5,6. Thalidomide and its modern analogues currently represent a backbone treatment of another disease: multiple myeloma (MM) 7. Here we would like to present a case of successful MM and GIA treatment with thalidomide.