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LEE, Mtm; CHEN, C. H; LANE, H. Y; CHANG, T. J; LIN, C. H; JOU, S. H; HOU, Y. M; FENG, J; LAI, T. J; TUNG, C. L; CHEN, T. J; CHANG, C. J; LEE, C. S; LUNG, F. W; CHEN, C. K; SHIAH, I. S; LIU, C. Y; TENG, P. R; CHEN, K. H; SHEN, L. J; CHENG, C. S; CHANG, T. P; LI, C. F; CHEN, C. C; CHOU, C. H; CHEN, C. Y; WANG, Kht; FANN, Csj; WU, J. Y; CHEN, Y. T; CHENG, A. T. A; CHONG, M. Y; OUYANG, W. C; CHIU, N. Y; CHUO, L. J; CHEN, C. Y; TAN, Hkl
Molecular psychiatry, 05/2011, Volume: 16, Issue: 5Journal Article
We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10(-7) (rs2709736) and 6.05 × 10(-6) (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P=9.74 × 10(-6)) and in CACNB2 (Calcium channel, voltage-dependent, β-2 subunit) gene (rs11013860, P=5.15 × 10(-5)), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10(-5) and P=1.48 × 10(-5), respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.
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