Routinely used immunoassays do not detect circulating anti‐GBM antibodies against native NC1 hexamer and EA epitope of the α3 chain of type IV collagen

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Routinely used immunoassays do not detect circulating anti‐GBM antibodies against native NC1 hexamer and EA epitope of the α3 chain of type IV collagen

Clavarino, Giovanna; Gauthier, Arnaud; Hellmark, Thomas; Carron, Pierre‐Louis; Giovannini, Diane; Colliard, Sophie; Dragon‐Durey, Marie‐ Agnès; Segelmark, Mårten; Cesbron, Jean‐Yves; Dumestre‐Pérard, Chantal

European Journal of Immunology, June 2018, Volume: 48, Issue: 6

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Detection of circulating anti‐GBM antibodies has a key role for the diagnosis of Goodpasture syndrome but immunoassays using purified or recombinant alpha3(IV)NC1 as antigen do not recognize all anti‐GBM antibodies. We show that anti‐GBM antibodies directed against epitopes in their native conformation or cryptic epitopes are detected by indirect immunofluorescence.

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