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Buenestado-Serrano, Sergio; Martínez-Lirola, Miguel; Herranz-Martín, Marta; Esteban, Jaime; Broncano-Lavado, Antonio; Molero-Salinas, Andrea; Sanz-Pérez, Amadeo; Blázquez, Jesús; Ruedas-López, Alba; Toro, Carlos; López-Roa, Paula; Domingo, Diego; Zamarrón, Ester; Ruiz Serrano, María Jesús; Muñoz, Patricia; Pérez-Lago, Laura; García de Viedma, Darío
Nature communications, 03/2024, Volume: 15, Issue: 1Journal Article
Mycobacterium abscessus is an opportunistic, extensively drug-resistant non-tuberculous mycobacterium. Few genomic studies consider its diversity in persistent infections. Our aim was to characterize microevolution/reinfection events in persistent infections. Fifty-three sequential isolates from 14 patients were sequenced to determine SNV-based distances, assign resistance mutations and characterize plasmids. Genomic analysis revealed 12 persistent cases (0-13 differential SNVs), one reinfection (15,956 SNVs) and one very complex case (23 sequential isolates over 192 months), in which a first period of persistence (58 months) involving the same genotype 1 was followed by identification of a genotype 2 (76 SNVs) in 6 additional alternating isolates; additionally, ten transient genotypes (88-243 SNVs) were found. A macrolide resistance mutation was identified from the second isolate. Despite high diversity, the genotypes shared a common phylogenetic ancestor and some coexisted in the same specimens. Genomic analysis is required to access the true intra-patient complexity behind persistent infections involving M. abscessus.
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