E-resources
-
Burtscher, Johannes; Burtscher, Martin; Millet, Grégoire P.
Redox biology, 07/2021, Volume: 43Journal Article
Mitochondria are central regulators of cellular metabolism, most known for their role in energy production. They can be “enhanced” by physical activity (including exercise), which increases their integrity, efficiency and dynamic adaptation to stressors, in short “mitochondrial fitness”. Mitochondrial fitness is closely associated with cardiorespiratory fitness and physical activity. Given the importance of mitochondria in immune functions, it is thus not surprising that cardiorespiratory fitness is also an integral determinant of the antiviral host defense and vulnerability to infection. Here, we first briefly review the role of physical activity in viral infections. We then summarize mitochondrial functions that are relevant for the antiviral immune response with a particular focus on the current Coronavirus Disease (COVID-19) pandemic and on innate immune function. Finally, the modulation of mitochondrial and cardiorespiratory fitness by physical activity, aging and the chronic diseases that represent the most common comorbidities of COVID-19 is discussed. We conclude that a high mitochondrial - and related cardiorespiratory - fitness should be considered as protective factors for viral infections, including COVID-19. This assumption is corroborated by reduced mitochondrial fitness in many established risk factors of COVID-19, like age, various chronic diseases or obesity. We argue for regular analysis of the cardiorespiratory fitness of COVID-19 patients and the promotion of physical activity – with all its associated health benefits – as preventive measures against viral infection. -Major COVID-19 risk factors are associated with reduced mitochondrial fitness.-SARS-coronavirus-2 infection is associated with various mitochondrial dysfunctions, also impairing the innate immune system.-Physical activity enhances immune functions, mitochondrial fitness and cardiorespiratory fitness.-Mitochondrial fitness may be an underlying molecular link between established risk factors for COVID-19.-Increasing mitochondrial and cardiorespiratory fitness, e.g. by appropriate physical activity, consequently may be a powerful preventive measure against viral infection, in particular by SARS-coronavirus-2.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.