This Review presents a concise, but not exhaustive, didactic overview of some of the main concepts and approaches related to “volatolomics”—an emerging frontier for fast, risk‐free, and potentially inexpensive diagnostics. It attempts to review the source and characteristics of volatolomics through the so‐called volatile organic compounds (VOCs) emanating from cells and their microenvironment. It also reviews the existence of VOCs in several bodily fluids, including the cellular environment, blood, breath, skin, feces, urine, and saliva. Finally, the usefulness of volatolomics for diagnosis from a single bodily fluid, as well as ways to improve these diagnostic aspects by “hybrid” approaches that combine VOC profiles collected from two or more bodily fluids, will be discussed. The perspectives of this approach in developing the field of diagnostics to a new level are highlighted. Ill‐gotten gains: Volatolomes enable identification of the collection of volatile organic compounds in a biological cell, tissue, or organism that are the by‐/end products of cellular processes in the living organism. The new analytical approach of volatolomics allows the large‐scale scientific study of chemical processes involving volatile organic compounds.