Both the rich mineralization in the Lower Yangtze Block (LYB) and the post-collisional mafic rocks in the Dabie Orogen (DBO) are closely related to the Cretaceous magmatism in east-central China. Various geodynamic models have been proposed for explaining the mechanism of the Cretaceous magmatism, but these models are controversial and even contradictory with each other, especially on the mechanism of adakites. A unified geodynamic model is required for explaining the magmatism in east-central China, in particular, the spatial and temporal correlations of magmatic activity in the DBO and that in the LYB. For this purpose, we apply teleseismic tomography to study P-wave velocity structure down to 800km depth beneath east-central China. A modified multiple-channel cross-correlation method is used to collect 28,805 high-quality P-wave arrival-time data from seismograms of distant earthquakes recorded by permanent seismic stations and our temporary stations in the study region. To remove the influence of crustal heterogeneity on the mantle tomography, we used the CRUST1.0 model to correct the teleseismic relative residuals. Our tomography revealed distinct high-velocity (high-V) anomalies beneath the DBO and two flanks of the LYB, and low-velocity (low-V) anomalies above the high-V zones. Combining our tomographic images with previous geological, geochemical and geophysical results, we infer that these high-V and low-V anomalies reflect the detached lithosphere and upwelling asthenospheric materials, respectively, which are associated with the Late Mesozoic dynamic process and the Cretaceous magmatism. We propose a double-slab subduction model that a ridge subduction yielded the adakitic rocks in the LYB during 150–135Ma and the subsequent Pacific Plate subduction played a crucial role in not only the formation of igneous rocks in the LYB but also remelting of the subducted South China Block beneath the DBO during 135–101Ma. •High-resolution tomograms reveal upper-mantle structure of east-central China.•Upper-mantle velocity anomalies reflect the Cretaceous magmatism.•A double-slab subduction model is proposed to explain all the results.