Inspired by the two-parameter Macdonald's deformation of the formulae for non simply laced simple Lie algebras, we propose a two-fold refinement of the partition function of the corresponding Chern-Simons theory on S3. It is based on a two-fold refinement of the Kac-Peterson formula for the volume of the fundamental domain of the coroot lattice of non simply laced Lie algebras. We further derive explicit integral representations of the two-fold refined Chern-Simons partition functions. We also present the corresponding generalized universal-like expressions for them. With these formulae in hand, one can try to investigate a possible duality of the corresponding Chern-Simons theories with hypothetical two-fold refined topological string theories.