Commercial crossbred pigs slaughtered at different live weights were used to investigate the effect of G1426A polymorphism in the melanocortin-4 receptor (MC4R) gene on carcass composition and meat quality traits. The significant effect of G/A substitution on backfat thickness (BF; P<0.01) was observed in pigs slaughtered at high live weight (123.0±6.5kg), but not in pigs slaughtered at low live weight (99.1±3.7kg). That was accompanied by tendency of decrease (P<0.10) in estimated lean meat percentage (LMP). The BF was higher and LMP was lower in AA compared to GG genotype (P<0.01). Meat quality traits were not affected by MC4R genotype. These results suggest that GG genotype could be favourable in pigs slaughtered at higher live weights due to lower BF and higher LMP.