E-resources
Peer reviewed
Open access
-
Kastelan, Darko; Dusek, Tina; Kraljevic, Ivana; Polasek, Ozren; Giljevic, Zlatko; Solak, Mirsala; Salek, Silva Zupancic; Jelcic, Jozo; Aganovic, Izet; Korsic, Mirko
Endocrine, 08/2009, Volume: 36, Issue: 1Journal Article
Objective Hypercoagulability is a commonly described complication in patients with Cushing’s syndrome. Recent clinical studies have indicated various abnormalities of coagulation and fibrinolysis parameters which may be related to that phenomenon. The aim of this study was to investigate the mechanisms underlying the hypercoagulable state in patients with Cushing’s syndrome. Research methods and procedures A wide range of serum markers involved in the processes of blood coagulation and fibrinolysis was measured in a group of 33 patients with Cushing’s syndrome and 31 healthy controls. No participant was taking medication which could influence the result or had known diseases, except hypertension and diabetes, which could affect blood coagulation or fibrinolysis parameters. Results Patients with Cushing’s syndrome had higher levels of clotting factors II ( P = 0.003), V ( P < 0.001), VIII ( P < 0.001), IX ( P < 0.001), XI ( P < 0.001) and XII ( P = 0.019), protein C ( P < 0.001), protein S ( P < 0.001), C1-inhibitor ( P < 0.001) and plasminogen activator inhibitor-1 (PAI-1) ( P = 0.004). The activity of fibrinolytic markers, plasminogen ( P < 0.001), antithrombin ( P < 0.001) and antithrombin antigen ( P = 0.001) was also increased in the patient group. Conclusion The study has demonstrated hypercoagulability in patients with Cushing’s syndrome manifest as increased prothrombotic activity and compensatory activation of the fibrinolytic system. We propose the introduction of thromboprophylaxis in the preoperative and early postoperative periods, combined with a close follow-up in order to prevent possible thromboembolic events in patients with Cushing’s syndrome.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.