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  • Probiotic cultivated meat: ...
    Kolodkin-Gal, Ilana; Dash, Orit; Rak, Roni

    Trends in biotechnology, March 2024, 2024-03-00, 20240301, Volume: 42, Issue: 3
    Journal Article

    Cultured meat production requires microcarriers, hydrogels, and scaffolds for 3D growth and support.Co-culturing techniques of probiotic bacteria and cell cultures are available.Probiotic bacteria efficiently produce antimicrobial substances, hydrogels, and fibril scaffolds.Probiotic bacteria can be genetically manipulated to grow only when it serves the cell culture.Probiotic bacteria can be genetically manipulated to serve as biosensors for lactate production and to remove lactate waste.Introducing probiotic bacteria into cultured meat can improve the design, function, and cost production and should be further explored. Cultivated meat is emerging to replace traditional livestock industries, which have ecological costs, including land and water overuse and considerable carbon emissions. During cultivated meat production, mammalian cells can increase their numbers dramatically through self-renewal/proliferation and transform into mature cells, such as muscle or fat cells, through maturation/differentiation. Here, we address opportunities for introducing probiotic bacteria into the cultivated meat industry, including using them to produce renewable antimicrobials and scaffolding materials. We also offer solutions to challenges, including the growth of bacteria and mammalian cells, the effect of probiotic bacteria on production costs, and the effect of bacteria and their products on texture and taste. Our summary provides a promising framework for applying microbial composites in the cultivated meat industry. Cultivated meat is emerging to replace traditional livestock industries, which have ecological costs, including land and water overuse and considerable carbon emissions. During cultivated meat production, mammalian cells can increase their numbers dramatically through self-renewal/proliferation and transform into mature cells, such as muscle or fat cells, through maturation/differentiation. Here, we address opportunities for introducing probiotic bacteria into the cultivated meat industry, including using them to produce renewable antimicrobials and scaffolding materials. We also offer solutions to challenges, including the growth of bacteria and mammalian cells, the effect of probiotic bacteria on production costs, and the effect of bacteria and their products on texture and taste. Our summary provides a promising framework for applying microbial composites in the cultivated meat industry.