Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance

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Treatment of Bloodstream Infections Due to Gram-Negative Bacteria with Difficult-to-Treat Resistance

Bassetti, Matteo; Vena, Antonio; Sepulcri, Chiara; Giacobbe, Daniele Roberto; Peghin, Maddalena

Antibiotics, 09/2020, Volume: 9, Issue: 9

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The rising incidence of bloodstream infections (BSI) due to Gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) has been recognized as a global emergency. The aim of this review is to provide a comprehensive assessment of the mechanisms of antibiotic resistance, epidemiology and treatment options for BSI caused by GNB with DTR, namely extended-spectrum Beta-lactamase-producing Enterobacteriales; carbapenem-resistant Enterobacteriales; DTR Pseudomonas aeruginosa; and DTR Acinetobacter baumannii.

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Bassetti, Matteo | Vena, Antonio | Sepulcri, Chiara | Giacobbe, Daniele Roberto | Peghin, Maddalena

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