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Ozono, Yoshinori; Nagata, Kenji; Hasuike, Satoru; Iwakiri, Hisayoshi; Nakamura, Kenichi; Tsuchimochi, Mai; Yamada, Yuri; Takaishi, Yuka; Sueta, Mitsue; Miike, Tadashi; Tahara, Yoshihiro; Yamamoto, Shojiro; Shide, Kotaro; Hidaka, Tomonori; Kubuki, Yoko; Kusumoto, Kazunori; Ochiai, Toshimasa; Kato, Junya; Komada, Naoto; Hirono, Shuichi; Kuroki, Kazuo; Shigehira, Masafumi; Shimoda, Kazuya
World journal of hepatology, 12/2017, Volume: 9, Issue: 36Journal Article
AIM To evaluate the efficacy and safety of a regimen containing sofosbuvir(SOF) and ledipasvir(LDV) in Japanese patients aged ≥ 75 years with hepatitis C genotype 1.METHODS This multicenter, retrospective study consisted of 246 Japanese patients with HCV genotype 1 at nine centers in Miyazaki prefecture in Japan. Demographic, clinical, virological, and adverse effects(AE)-related data obtained during and after SOF/LDV therapy were collected from medical records. These patients were divided into two groups, younger(aged < 75 years) and elderly(aged ≥ 75 years). Virological data and AEs were analyzed by age group.RESULTS The sustained virological response(SVR) rates at 12 wk after treatment were 99.2%, 99.4%, and 98.7% in the overall population and in patients aged < 75 and ≥ 75 years, respectively. Common AEs during therapy were headache, pruritus, constipation, and insomnia. These occurred in fewer than 10% of patients, and their incidence was not significantly different between the younger and elderly groups. Two patients discontinued treatment, one due to a skin eruption and the other due to cerebral bleeding. CONCLUSION Compared with younger patients, elderly patients had a similar virological response and tolerance to SOF/LDV therapy.
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