Disentangling the relationship between tumor genetic programs and immune responsiveness

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Disentangling the relationship between tumor genetic programs and immune responsiveness

Bedognetti, Davide; Hendrickx, Wouter; Ceccarelli, Michele; Miller, Lance D; Seliger, Barbara

Current opinion in immunology, 04/2016, Volume: 39

Journal Article

Highlights • The Th-1 cancer phenotype is characterized by responsiveness to immunotherapy. • This phenotype is accompanied by activation of counter-regulatory mechanisms. • Tumor genetic program modulates the development of the Th-1 cancer phenotype. • Oncogenic pathways can be targeted to enhance the efficacy of cancer immunotherapy.

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Bedognetti, Davide | Hendrickx, Wouter | Ceccarelli, Michele | Miller, Lance D | Seliger, Barbara

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