Caregiving burden is set to increase with the rising incidence of cancer globally. The meta-analysis seeks to investigate the prevalence of suicide, suicidal ideation and self-harm among the caregivers of patients with cancer (CPCs). This PRISMA-adherent systematic review involved a systematic search of PubMed, Embase, Cochrane and PsycINFO for all studies that evaluated the prevalence of suicide, suicidal ideation and self-harm in CPCs. Random effects meta-analyses were used for primary analysis. Eleven studies were included. Meta-analyses indicated that the prevalence of suicidal ideation in CPCs was 11% (95%CI:6–18), suicide prevalence was 6% (95%CI:3–12), and self-harm prevalence was 15% (95%CI:8–26). Subgroup analyses revealed that CPCs above the age of 50 experienced a greater prevalence of suicidal ideation (17%, 95%CI:10–28) as compared to CPCs below 50 (6%, 95%CI:3–12). Family caregivers particularly spouses were also found to have a higher prevalence of suicidal ideation (17%, 95%CI:13–23), as compared to children (5%, 95%CI:2–10) or mothers (3%, 95%CI:1–8). Systematic review found that having a pre-existing mental health condition and lower socioeconomic status increased likelihood of suicidality. We highlight the need for more support of CPCs at risk of suicidality. Additional research is warranted to identify other risk and protective factors. •Statistically high prevalence of suicide ideation, suicide and self-harm in caregivers of cancer patients.•Cancer caregivers above 50 years old compared to those below 50 experienced greater suicide ideation.•Family caregivers particularly spouses compared to children or mothers experienced greater suicide ideation.•Pre-existing mental health condition and lower socioeconomic status increased the likelihood of suicidality.