Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach

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Prolonged and severe SARS-CoV-2 infection in patients under B-cell-depleting drug successfully treated: A tailored approach

D’Abramo, Alessandra; Vita, Serena; Maffongelli, Gaetano; Mariano, Andrea; Agrati, Chiara; Castilletti, Concetta; Goletti, Delia; Ippolito, Giuseppe; Nicastri, Emanuele

International journal of infectious diseases, 06/2021, Volume: 107

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•Anti-CD20 monoclonal antibody are widely used in haematological/autoimmune disease.•B-cell depletion is associated with severe and persistent SARS-CoV-2 infection.•Monoclonal antibody anti-SARS-CoV-2 spike glycoprotein as a therapeuthic option.•The management of immunosuppressed patients should be modify in pandemic COVID-19? Prolonged B-cell depletion due to anti-CD20 monoclonal antibody (mAbs) therapy impairs the adaptive immune response, causing severe manifestations during COronaVIrus Disease-2019 (COVID-19). The cases of two patients under anti-CD20 therapy who experienced prolonged and severe COVID-19 successfully treated with mAbs against Severe Acute Respiratory Syndrome-CoV-2 spike proteins are reported.

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