EFGR -mutant lung adenocarcinoma and Li-Fraumeni syndrome: Report of two cases and review of the literature

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EFGR -mutant lung adenocarcinoma and Li-Fraumeni syndrome: Report of two cases and review of the literature

Ricordel, Charles; Labalette-Tiercin, Marie; Lespagnol, Alexandra; Kerjouan, Mallorie; Dugast, Catherine; Mosser, Jean; Desrues, Benoit; Léna, Hervé

Lung cancer, 01/2015, Volume: 87, Issue: 1

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Highlights • EGFR-mutated lung adenocarcinoma belongs to the spectrum of predisposed neoplasms in LFS. • We provide the first description of resistance mutation to EGFR-TKI in a patient with LFS and lung adenocarcinoma. • Response to targeted therapy may benefit to the same extent to LFS patient as in the general population.

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