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Peer reviewed
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Yang, F; Zhou, L; Wang, D; Wang, Z; Huang, Q.-Y
Neuroscience, 09/2015, Volume: 304Journal Article
Highlights • Our results show that minocycline reduces hypoxia-induced increases in BBB permeability and HIF-1α. • Minocycline also increases the hypoxia-induced reduction of PHD-2 and SIRT-3. • These effects of minocycline are abolished by siRNA-mediated knockdown of SIRT-3 in the brain. • Minocycline inhibits HIF-1α-mediated cellular responses and protects the BBB through a SIRT-3/PHD-2-dependent pathway.
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