E-resources
Peer reviewed
Open access
-
Kameda, Takuro; Shide, Kotaro; Kamiunten, Ayako; Kogure, Yasunori; Morishita, Daisuke; Koya, Junji; Tahira, Yuki; Akizuki, Keiichi; Yokomizo-Nakano, Takako; Kubota, Sho; Marutsuka, Kosuke; Sekine, Masaaki; Hidaka, Tomonori; Kubuki, Yoko; Kitai, Yuichi; Matsuda, Tadashi; Yoda, Akinori; Ohshima, Takayuki; Sugiyama, Midori; Sashida, Goro; Kataoka, Keisuke; Ogawa, Seishi; Shimoda, Kazuya
Communications biology, 11/2022, Volume: 5, Issue: 1Journal Article
Adult T-cell leukemia/lymphoma (ATL) is caused by human T-cell leukemia virus type 1 (HTLV-1). In addition to HTLV-1 bZIP factor (HBZ), a leukemogenic antisense transcript of HTLV-1, abnormalities of genes involved in TCR-NF-κB signaling, such as CARD11, are detected in about 90% of patients. Utilizing mice expressing CD4 T cell-specific CARD11(E626K) and/or CD4 T cell-specific HBZ, namely CARD11(E626K) mice, HBZ transgenic (Tg) mice, and CARD11(E626K) ;HBZ Tg double transgenic mice, we clarify these genes' pathogenetic effects. CARD11(E626K) and HBZ Tg mice exhibit lymphocytic invasion to many organs, including the lungs, and double transgenic mice develop lymphoproliferative disease and increase CD4 T cells in vivo. CARD11(E626K) and HBZ cooperatively activate the non-canonical NF-κB pathway, IRF4 targets, BATF3/IRF4/HBZ transcriptional network, MYC targets, and E2F targets. Most KEGG and HALLMARK gene sets enriched in acute-type ATL are also enriched in double transgenic mice, indicating that these genes cooperatively contribute to ATL development.
Author
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.