Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson’s disease

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Brain iron accumulation exacerbates the pathogenesis of MPTP-induced Parkinson’s disease

You, L.-H; Li, F; Wang, L; Zhao, S.-E; Wang, S.-M; Zhang, L.-L; Zhang, L.-H; Duan, X.-L; Yu, P; Chang, Y.-Z

Neuroscience, 01/2015, Volume: 284

Journal Article

Highlights • CP−/− mice and mice that received FAC had high levels of brain iron. • Brain iron accumulation exacerbated TH-positive neurons apoptosis in MPTP-treated mice. • DFO reduced the neuronal damage in MPTP-treated CP−/− mice. • Increased oxidative stress was involved in cell apoptosis exacerbated by the increased brain iron.

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