E-resources
-
Nin, Fumiaki; Hibino, Hiroshi; Doi, Katsumi; Suzuki, Toshihiro; Hisa, Yasuo; Kurachi, Yoshihisa
Proceedings of the National Academy of Sciences - PNAS, 02/2008, Volume: 105, Issue: 5Journal Article
An endocochlear potential (EP) of +80 mV is essential for audition. Although the regulation of K⁺ concentration (K⁺) in various compartments of the cochlear stria vascularis seems crucial for the formation of the EP, the mechanism remains uncertain. We have used multibarreled electrodes to measure the potential, K⁺, and input resistance in each compartment of the stria vascularis. The stria faces two fluids, perilymph and endolymph, and contains an extracelluar compartment, the intrastrial space (IS), surrounded by two epithelial layers, the marginal cell (MC) layer and that composed of intermediate and basal cells. Fluid in the IS exhibits a low K⁺ and a positive potential, called the intrastrial potential (ISP). We found that the input resistance of the IS was high, indicating this space is electrically isolated from the neighboring extracellular fluids. This arrangement is indispensable for maintaining positive ISP. Inhibiting the K⁺ transporters of the stria by anoxia, ouabain, or bumetanide caused the K⁺ of the IS to increase and the intracellular K⁺ of MCs to decrease, reducing both the ISP and the EP. Calculations indicate that the ISP represents the K⁺ diffusion potential across the apical membranes of intermediate cells through Ba²⁺-sensitive K⁺ channels. The K⁺ diffusion potential across the apical membranes of MCs also contributes to the EP. Because the EP depends on two K⁺ diffusion potentials and an electrical barrier in the stria vascularis, interference with any of these elements can interrupt hearing.
Author
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.