E-resources
Peer reviewed
Open access
-
Ju, Qian; Huang, Rong; Hu, Ruimin; Fan, Junjie; Zhang, Dinglin; Ding, Jun; Li, Rong
Drug delivery 30, Issue: 1Journal Article
Osteosarcoma is the most common malignant tumor in the skeletal system with high mortality. Phytic acid (PA) is a natural compound extracted from plant seeds, which shows certain antitumor activity and good bone targeting ability. To develop a novel theranostics for magnetic resonance imaging (MRI) and targeting therapy of osteosarcoma, we employed PA to modify manganese dioxide nanoparticles (MnO 2 @PA NPs) for osteosarcoma treatment. The MnO 2 NPs oligomer was formed by PA modification with uniformed size distribution and negative zeta potential. Fourier-transform infrared spectroscopy, X-ray diffraction, energy dispersive spectroscopy, X-ray photoelectron spectroscopy, and thermogravimetric analysis demonstrated that PA has been successfully modified on MnO 2 NPs, and the structure of MnO 2 @PA NPs is amorphous. In vitro experiments demonstrated that MnO 2 @PA NPs oligomer can be efficiently internalized by tumor cell, and the internalized NPs can react with H 2 O 2 under acid microenvironment to produce Mn 2+ and O 2 . In vivo experiments demonstrated that MnO 2 @PA NPs oligomer can passively accumulate in tumor tissue, and the accumulated NPs can produce Mn 2+ and O 2 for MRI and targeting therapy of osteosarcoma. In conclusion, we prepared a novel bone-targeting nano theranostics for MRI and therapy of osteosarcoma.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|
Source: Personal bibliographies
and: SICRIS
The material is available in full text. If you wish to order the material anyway, click the Continue button.