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Laktašić Žerjavić, Nadica; Pap, Mislav; Žagar, Iva; Kovač Durmiš, Kristina; Perić, Porin
Reumatizam, 12/2022, Volume: 68, Issue: 2Journal Article
Sjögrenov sindrom (SS) kronična je autoimuna bolest u kojoj limfocitna infiltracija dovodi do progresivnog oštećenja egzokrinih žlijezda i sljedstvenoga suhog sindroma. Najčešće zahvaća suzne i slinovne žlijezde, a manje često se javljaju simptomi egzokrinih žlijezda druge lokalizacije, artritis, miozitis, vaskulitis sa zahvaćanjem kože i živčanog sustava, intersticijska bolest pluća i bubrežna bolest. Najteža komplikacija je razvoj limfoproliferativne bolesti, u prvom redu ne-Hodgkinovog limfoma (NHL-a). U radu prikazujemo bolesnicu koja je nakon 23 godine trajanja primarnog SS-a razvila indolentni ekstranodalni B-NHL CD20 pozitivni limfom tipa MALT uz dobar odgovor na liječenje rituksimabom.
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