Clinical failure of vancomycin in a dialysis patient with methicillin-susceptible vancomycin-heteroresistant S. aureus

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Clinical failure of vancomycin in a dialysis patient with methicillin-susceptible vancomycin-heteroresistant S. aureus

Fusco, Dahlene N; Alexander, Elizabeth L; Weisenberg, Scott A; Mediavilla, Jose R; Kreiswirth, Barry N; Schuetz, Audrey N; Jenkins, Stephen G; Rhee, Kyu Y

Diagnostic microbiology and infectious disease, 10/2009, Volume: 65, Issue: 2

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Abstract We report a case of recurrent Staphylococcus aureus bacteremia in a patient who failed vancomycin due to a vancomycin-heteroresistant strain lacking methicillin resistance. Although initial isolates were susceptible, isolates obtained after vancomycin chemotherapy were vancomycin heteroresistant. This case thus illustrates the clinical emergence of vancomycin heteroresistance.

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