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Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophagesSzebeni, Janos ...Dipyridamole (DPM) is commonly used as a coronary vasodilator and inhibitor of platelet aggregation in the treatment of cardiovascular diseases. We report here that DPM potentiates the inhibitory ... effects of 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine against human immunodeficiency virus type 1 (HIV-1) in human monocyte-macrophages. At the same concentrations, DPM does not potentiate the toxic effects of AZT on these cells or on human bone marrow (granulocyte-monocyte) progenitor cells. Since monocyte-macrophage lineage cells appear to be the major reservoir for HIV-1 in vivo, these findings suggest the possibility of using DPM or its analogues in combination chemotherapy of HIV infections.Vir: Proceedings of the National Academy of Sciences of the United States of America. - ISSN 0027-8424 (Letn. 86, št. 10, 1989, str. 3842-3846)Vrsta gradiva - članek, sestavni delLeto - 1989Jezik - angleškiCOBISS.SI-ID - 2628825
Avtor
Szebeni, Janos |
Wahl, Sharon M. |
Popovic, Mikulas |
Wahl, Larry M. |
Gartner, Suzanne |
Fine, Robert L. |
Skalerič, Uroš, 1945-2023 |
Friedmann, Robert M. |
Weinstein, John N.
Teme
Antiviral agents |
Dipyridamole |
Administration and dosage |
Hiv |
Drug effects |
Virus replication |
Drug effects |
Zidovudine |
Administration and dosage |
Biological transport |
Bone marrow |
Cytology |
Drug effects |
Cell survival |
Drug effects |
Dideoxynucleosides |
Metabolism |
Drug synergism |
Hiv |
Growth and development |
Interferon type i |
Biosynthesis |
Macrophages |
Drug effects |
Monocytes |
Drug effects
Vnos na polico
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