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Use of microcalorimetry in determination of stability of enalapril maleate tablet formulationsSimončič, Zvone ...The stability properties of enalapril maleate (EM) and of different tablet formulations including EM were studied by isothermal microcalorimetry and by high performance liquid chromatography (HPLC). ... It was shown that water content of the sample and elevated temperature have a high impact on stability properties of the substance itself and of the formulations including this substance. The degradation is more extensive at higher water content and at elevated temperature. The type of the tablet formulation (5 or 20 mg EM tablet formulation) also has an impactČ the 5 EM tablet formulation is the less stable one. The heat output of individual tablet formulations was used to evaluate the enthalpy changes and to calculate the difference in the amount ofdegraded EM between various samples. These results agreed satisfactorily with those obtained by HPLC. Isothermal microcalorimetry proved to be a fast and predictive method that could be used in preformulation studies to accelerate the pharmaceutical development and shorten the time before launching the product to the market.Vir: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 342, no. 1/2, 2007, str. 145-151)Vrsta gradiva - članek, sestavni delLeto - 2007Jezik - angleškiCOBISS.SI-ID - 28844037
Avtor
Simončič, Zvone |
Zupančič, Polonca, farmakologinja |
Roškar, Robert, 1975- |
Gartner, Andrej |
Kogej, Ksenija |
Kmetec, Vojko
Teme
farmacija |
farmakologija |
eksperimetalna kemija |
analitska kemija |
zdravila |
oblikovanje tablet |
aktivna substanca |
enalapril maleat |
stabilnost |
določevanje stabilnosti |
izotermična mikrokalorimetrija |
kromatografska analiza |
tekočinska kromatografija visoke ločljivosti |
HPLC |
isothermal microcalorimetry |
chromatography |
enalapril maleate |
stability |
active substance |
formulation
vir: International journal of pharmaceutics. - ISSN 0378-5173 (Vol. 342, no. 1/2, 2007, str. 145-151)
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Simončič, Zvone | 24524 |
Zupančič, Polonca, farmakologinja | |
Roškar, Robert, 1975- | 23549 |
Gartner, Andrej | 04339 |
Kogej, Ksenija | 04614 |
Kmetec, Vojko | 01466 |
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