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Fakulteta za farmacijo, Ljubljana (FFALJ)
  • Three day environmental exposure may trigger oxidative stress development and provoke adaptive response resulting in altered antioxidant activity
    Zimet, Zlatko ...
    We aimed to investigate the polluted working environment triggers oxidative stress and alter enzymatic antioxidant activity by a short-term interval. Methods: The experimental study, performed in ... 2014, involved 94 workers from the Velenje Coalmine in Slovenia, arranged into three groups according to a number of consecutive working days in a mineshaft, supported by a control group. Levels of the antioxidant enzymes (GPx, CAT, SOD) together with TAC (the combined effect of all antioxidants) and 8-isoprostane (a biological marker of oxidative stress/damage) were measured in human plasma. Results: Workers occupationally exposed for three consecutive working days had significantly increased 8-isoprostane biomarker, a parameter of oxidative stress (P<0.001). The antioxidant levels of TAC (P<0.001), CAT (P<0.001) and SOD (P<0.001) were all significantly decreased compared to a control group. Conclusion: Workers in polluted working environment had significantly increased oxidative stress and altered antioxidant activity already on a third consecutive working day.
    Vir: Iranian journal of public health. - ISSN 2251-6085 (Vol. 48, no. 7, 2019, str. 1284-1291)
    Vrsta gradiva - članek, sestavni del ; neleposlovje za odrasle
    Leto - 2013
    Jezik - angleški
    COBISS.SI-ID - 4741489

vir: Iranian journal of public health. - ISSN 2251-6085 (Vol. 48, no. 7, 2019, str. 1284-1291)

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