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Fakulteta za farmacijo, Ljubljana (FFALJ)
  • Selective galectin-8N ligands [Elektronski vir] : the design and synthesis of phthalazinone-d-galactals
    van Klaveren, Sjors ...
    Ligand selectivity among the highly conserved galectins has been an ever-challenging objective. For galectin-8, a protein ubiquitous in both pathology and tissue distribution, we report ... phthalazinone–galactals that show excellent selectivity for the galectin-8 N-terminal domain. A dissection of structure-activity relationships of the phthalazinone and an extensive molecular dynamics meta-analysis accompany the discovery of the selective galectin-8N ligands presented here. These selective compounds will facilitate the study of galectin-8 biology and may have pharmaceutical relevance in the wide range of galectin-8 associated pathologies.
    Vir: ChemMedChem. - ISSN 1860-7187 (Vol. 17, iss. 6, art. e202100575, 2022, 8 str.)
    Vrsta gradiva - e-članek ; neleposlovje za odrasle
    Leto - 2022
    Jezik - angleški
    COBISS.SI-ID - 89783811

    Povezava(-e):

    https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/cmdc.202100575
    DOI

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