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  • Contribution of complement to hypersensitivity reactions = Vloga komplementarnega sistema pri preobčutljivosti
    Vogel, Heiko ; Kirschfink, Michael
    The concept that antigen-antibody complexes are causal to certain inflammatorydiseases was first suggested by Clemens von Pirquet (1911). Today,it is well established that cell binding of ... (auto)antibodies or the deposition of immune complexes in tissues are the pathogenic mechanisms underlying tissue injury in a number of diverse clinical conditions affecting the skin, joints, blood cessels and renal glomeruli. Initial approaches to theunderstanding of these conditions have stresses the roles of both the activation of the complement system and the accumulation of neutrophils as themain molecular and cellular mechanisms explaining the sequence of events leading to tissue damage. This brief review adresses basic mechanisms of complement activation in antibody-mediated inflammation and describes its contribution to hypersensitivity reactions.
    Vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 38, supl. 7, nov. 1999, str. 13-20)
    Vrsta gradiva - članek, sestavni del
    Leto - 1999
    Jezik - angleški
    COBISS.SI-ID - 10931929

vir: Medicinski razgledi. Supplement. - ISSN 0353-3484 (Letn. 38, supl. 7, nov. 1999, str. 13-20)

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